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Do you suffer from depression or anxiety? You may have pyroluria

Pyroluria is a genetic abnormality in hemoglobin synthesis that affects up to 10% of the population (although most people don’t know they have it) and often leads to mental health disorders such as depression and anxiety and, in severe cases, , can cause bipolar disorder and schizophrenia if left untreated. Memory problems, insomnia, learning disabilities, low stress tolerance, and irritability may be additional symptoms, as well as a variety of other signs and symptoms (see below). It can be triggered by ongoing stress or a traumatic event, although there are often no known triggers, and symptoms usually begin during the teens or early 20s.

People with this biochemical imbalance have high levels of pyrrole in their body, which is a neurotoxic substance that affects the nervous system and brain and when levels are elevated it can trigger mental illness. Pyrroles are a by-product produced during the production of red blood cells (RBCs) and, in patients without pyroluria, are effectively broken down and eliminated. However, when someone has undiagnosed and untreated pyroluria, pyrroles are not broken down and eliminated efficiently enough and accumulate in the body and bind to certain essential nutrients such as vitamin B6, zinc, magnesium, manganese, biotin and others, leaving the body. depleted of these nutrients.

Treating the condition with the correct supplementation, such as a coenzyme form of B6 and zinc, as well as manganese, biotin, magnesium, niacin, omega 6 fatty acids (particularly arachidonic acid), vitamin C, and other nutrients, reduces toxic levels of pyrrole. and increases these essential nutrients. Supplementing with a coenzyme B6 also allows the body to create serotonin that it cannot make without optimal levels of B6. If OCD, Bipolarity or Schizophrenia have already developed, additional supplements such as NAC for OCD and Bipolarity or Vitamin B3 for Schizophrenia may be required, so an individualized approach is necessary. Treatment with the correct supplementation and proper diet generally results in complete resolution of symptoms for patients with Pyroluria, as long as they continue to take the supplements and eat an adequate and healthy diet.

The following signs and symptoms may occur in people suffering from Pyroluria. If you have at least 8 of these symptoms, see a naturopathic doctor or doctor for testing:

Anxiety; nervousness; severe internal stress


Little ability to cope with stress.

emotional instability

Mood swings or temper outbursts

Panic attacks

addictive personality; substance abuse

Cravings for foods that are high in carbohydrates and foods that are high in sugar.


Obsessive Compulsive Disorder (OCD)

Episodic anger/temper outbursts/explosive temper

histrionic (dramatic)

Arguing/enjoying a discussion



pessimistic thinking patterns

Digestive problems, for example, abdominal tenderness; constipation, IBS, etc.

Glucose intolerance/hypoglycemia


Little or no memory of dreams

White spots on the nails

Frequent infections, inc. colds; poor immune function

Poor morning appetite and tendency to skip breakfast.

Frequent and unexplained nausea

Much greater capacity and alertness at night, compared to the mornings

Increased sensitivity to bright light, loud noises, smells, touch.

Joint pain, especially in the knees/legs; Restless leg syndrome; crispy knees

Food allergies or intolerances/environmental allergies/sensitivities

drug sensitivities

Learning problems (eg, dyslexia, dyscalculia, etc.); auditory processing disorder

Behavior problems in children and adolescents such as oppositional defiant disorders

Antisocial behavior



poor short-term memory

Skin problems like acne, eczema, psoriasis, and dry skin

Significant growth after age 16.

delayed onset of puberty

Crowded teeth and poor tooth enamel; receding gums/gum disease; sensitive teeth

Cold hands and feet even in summer

Sweet and fruity breath and body odor

Abnormal distribution of body fat (tendency for abdominal fat)

Stretch marks

thick eyebrows

stunted growth


motion sickness

irregular menstruation


impotence in men


Droopy eyelid(s)

Pale skin + poor tan + sunburns easily

Likes routine (especially as a child)

emotional withdrawal

social retreat

Gluten intolerance or celiac disease

Eosinophilia (elevated levels of eosinophils, a type of white blood cell)

Anemia/low iron levels

elevated copper levels

Elevated levels of heavy metals


Emotional lability (exaggerated emotional reaction, for example, laughing or crying uncontrollably or inappropriate emotions, for example, excessive anger or irritability or laughing when something is sad), especially when stressed or tired.

disordered perception; loss of reality

hallucinations; hallucinations


Suicidal tendencies

Autism, Asperger’s

Bipolar (manic depression)


Down’s Syndrome

Epilepsy; seizures

Tourette syndrome

Acute intermittent porphyria

Latent acute intermittent porphyria (Note: The porphyrias are a group of rare genetic disorders related to heme production)

Dissociative identity disorder (DID) – more commonly known as multiple personality disorder

If you suffer from depression, anxiety, or another mental health disorder and have 8 or more of the signs or symptoms listed above, see a naturopathic doctor or doctor for testing and advice on the best treatments for pyroluria. The test is a non-invasive urine test and if the test shows you have pyroluria, your doctor will provide treatment recommendations that will take into account your individual requirements.

Please share this article in case it can help in the lives of others who may unknowingly have this condition and suffer unnecessarily when simple treatments exist.

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